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Tresaderm by Merial

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Tresaderm is a refrigerated item and requires overnight shipping.  You may consider POSATEX, BAYTRIL OTIC or MOMENTAMAX OTIC as alternatives at a lower cost.


Generic Name:

Thiabendazole + Neomycin sulfate + Dexamethasone

General Description:

This drug is a combination of medications that are commonly used in dogs and cats to treat ear disorders and certain skin conditions.

What is this drug?
  • A combination of an antibiotic (neomycin sulfate), antifungal (thiabendazole), and corticosteroid (dexamethasone)
  • Applied directly in the ear or applied directly on the skin
Reasons for prescribing:
  • To treat ear infections
  • To treat certain bacterial, fungal and inflammatory skin disorders
What dogs/cats should not take this medication?
  • Animals with a ruptured ear drum
  • Animals that may be pregnant
  • Animals with a known hypersensitivity or allergy to this drug should not take this medication

Read and follow the prescription label carefully.
Give the exact amount prescribed and only as often as directed.
Give this medication for as long as your veterinarian directs. Application and use of this product should be limited to no longer than 7 days.
Do not skip doses or stop giving the medication without consulting your veterinarian.
Dose adjustments may be made based upon an assessment of how your dog or cats is responding clinically.
It may be necessary to clip the hair around the affected area to assist with the treatment of the skin infection. Use a skin cleansing solution to clean the lesion and adjacent area.
Your veterinarian will need to examine your pet’s ear prior to use of this product. This product should not be used in animals with a perforated ear drum. It may be necessary to clip excess hair from around the ear to assist with cleaning and applying ear medications. Remove any debris, or crusty material with a suitable non-irritating ear cleaning solution.
Wait until after the ear or skin is clean and dry before administering any medications into the ear or onto the skin.
The nozzle design will safely allow partially insertion into the ear canal. Apply the prescribed amount and gently massage ear to distribute medication.
If your pet requires more than one ear medication, discuss with your veterinarian if it is preferable to administer the medications at different times of the day.
Avoid getting this medication in your pet's eyes, nose, or mouth.
Always wash your hands before and after applying any topical medication.
If treating a potentially contagious skin condition, consider using gloves to apply the medication and consult with your veterinarian about further measures to avoid spreading the infection.
If you are having difficulty applying the medication or your pet is in discomfort, contact your veterinarian.
Call ahead for refills.
Ideally, give this medication at the same time(s) daily.

Administration of ear medications
  • Wash your hands before applying any ear medication
  • The ear should be clean and dry prior to administering medications
  • Check label directions and shake bottle if necessary
  • Lift the ear flap so that it is pointing straight up
  • Hold the medication bottle insertion tip into the canal
  • Gently squeeze the desired amount of medication into the canal
  • Massage near the base of the ear to encourage the medication to work into the deeper aspects of the canal
  • Wash your hands after applying any ear medication
  • Always praise and reward your pet to encourage cooperation
What if a dose is missed?

If a dose is missed, give it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask a veterinarian before giving medication?

Talk to your veterinarian about:

  • When your pet will need to be rechecked
  • How often does your pet's ears need to be cleaned
  • What tests may need to be performed prior to and during treatment with this drug
  • What are the risks and benefits of using this drug

Tell your veterinarian about:

  • If your pet has experienced previous ear problems
  • If your pet has experienced side-effects on other drugs/products
  • If your pet has experienced digestive upset now or ever
  • If your pet has experienced liver or kidney disease now or ever
  • If your pet has experienced any other medical problems or allergies now or ever
  • All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet’s medications can be given together.
  • If your pet is pregnant, nursing or if you plan to breed your pet
Storage and Warnings:

Thiabendazole + Neomycin + Dexamethasone should be stored in a childproof container in the refrigerator, but do not freeze.
Keep this and all medication out of reach of children and pets.
Avoid contact with eyes. Prevent oral ingestion of this medication.

Potential side effects:
  • Rarely, this medication may cause local irritation, swelling or redness (due to neomycin sensitivity) in the medication application area. Contact your veterinarian if this occurs.
  • If the animal ingests this product, receives long term treatment or is given high doses, possible side effects related to dexamethasone could include an increase in thirst and appetite
  • This medication can affect the gastrointestinal system causing vomiting and diarrhea
  • This medication can cause weight gain and behaviour changes
  • Applying the medication to open lesions may cause some pain (for less than 5 minutes)
  • Discontinue use and contact your veterinarian if hearing loss is noted during treatment
  • This medication when given at high doses or for prolonged periods can affect the immune system causing an increased susceptibility to infections and delayed wound healing
  • Chronic use can suppress the function of the adrenal glands
  • It is important to stop therapy and contact your veterinarian immediately if you think you pet has a medical problem or side effect from this product's therapy
Can this drug be given with other drugs?
  • Yes, but possible interactions may occur with aminophylline, gentamicin, NSAIDs (aspirin, carprofen, deracoxib or etodolac), other corticosteroids and theophylline
  • Do not give new food or medications without first talking to your veterinarian
  • If your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian

Contact your veterinarian immediately if you pet has accidentally ingested this medication or has received more than the prescribed amount.

What else should I know?

Notify your veterinarian if your animal’s condition does not improve or worsens despite this treatment.

As with all prescribed medicines, thiabendazole + neomycin + dexamethasone should only be used on the pet for which it was prescribed.

It should be used only for the condition for which it was prescribed. Never use ear or skin medications in the eye.

It is important to have any ear problems assessed by a veterinarian prior to applying any medications as incorrect treatment can result in damage to the ear.

Discuss with your veterinarian what is recommended to treat underlying conditions that may predispose your pet to reoccurring ear problems.

This is just a summary of information about thiabendazole + neomycin + dexamethasone. If you have any questions or concerns about thiabendazole + neomycin + dexamethasone or for the condition it was prescribed, contact your veterinarian.

Thiabendazole/ Neomycin/Dexamethasone

Common Drug Name
Thiabendazole with Dexamethasone and Neomycin

Common Brand Names
No generic products are available.

Store tightly closed, in a refrigerator.

Thiabendazole is an antifungal agent. Dexamethasone is a corticosteroid. Neomycin is an antibiotic. The combination is approved for the treatment of inflammation and bacterial and dermatophyte fungal infections (ring­worm) of the ear and skin in dogs and cats.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty applying the medication, contact your veterinarian.
The ear or area of skin should be thoroughly cleaned and dried before treatment. For the ear, remove any debris, or crusty material, etc. with a suitable non­irritating ear cleaning solution. For the skin, use a skin cleansing solution to clean the lesion and adjacent area. Clip any excessive hair from the ear or treatment area, as directed by your veterinarian. 
The design of the nozzle will safely allow you to partially insert it into the ear. Apply the prescribed amount and gently massage the ear to distribute the medication.
If you miss a dose, apply it as soon as you remember. If it is almost time for the next dose, skip the application you missed and go back to the regular schedule. 
This medication should only be given to the pet for whom it was prescribed. 

Possible Side Effects
In rare instances, an animal may be sensitive to neomycin, causing redness in the area the medication was applied. If your pet is experiencing this, contact your veterinarian.
If there are open lesions, applying the medication may cause some pain, lasting 2-5 minutes.
If ingested, or given at high doses or for prolonged periods of time, side effects related to the dexamethasone may be seen. The most common effect is an increase in the amount of drinking and urinating. Less commonly may see an increased appetite and weight gain, panting, diarrhea, vomiting, and behavior changes. These effects may be eliminated or reduced by decreasing dosage or frequency of administration, as recommended by your veterinarian.
Contact your veterinarian if side effects are noticed or if the condition worsens.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Do not use in animals hypersensitive (allergic) to any of the ingredients.
Corticosteroids, if given at high doses or for extended periods, can cause premature  birth. In dogs, rabbits, and rodents, corticosteroids can cause birth defects.
Prevent oral ingestion of the medication.
Avoid contact with the eyes.
A veterinary exam of the ear is necessary prior to use of this product. It should not be used in animals with a perforated eardrum.
Corticosteroids, if given at high doses or for extended periods, can cause delayed wound healing and immunosuppression resulting in an increased risk of bacterial or fungal infections.
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with thiabendazole/neomycin/dexamethasone.

Drug, Food, and Test Interactions
Consult your veterinarian before using thiabendazole/neomycin/dexmethasone with other medications, including vitamins and supplements, non-steroidal anti­inflammatory drugs (NSAIDs) such as aspirin, carprofen (Rimadyl), deracoxib (Deramaxx), or etodolac (EtoGesic), other corticosteroids, or gentamicin, since interactions may occur. 

Signs of Toxicity/Overdose
Adverse reactions and toxicities are unlikely if used according to directions. If you know or suspect your pet has had an overdose, or if you observe any unusual signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times. Always consult your own veterinarian for specific advice concerning the treatment of your pet.


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