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Baytril Otic

Baytril Otic by Bayer Animal Health Direct

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Baytril® Otic Antibacterial-Antimycotic Emulsion

Generic Name:

Enrofloxacin-Silver sulfadiazine otic
General Description:

Enrofloxacin + Silver sulfadiazine Otic is a soothing topical fluoroquinolone antibiotic emulsion used to rapidly treat susceptible bacterial and fungal ear infections in dogs. Available in 15 mL and 30 mL dropper bottles.

What is this drug?
  • Enrofloxacin + Silver sulfadiazine Otic is a combination of a fluoroquinolone antibiotic and a potent antifungal
  • Used topically in the ear
Reasons for prescribing:
  • Effective against many bacteria and fungus types with few side effects
  • Reduces ear inflammation and improves epidermal repair
What dogs/cats should not take this medication?
  • This product is approved for use only in dogs
  • Young, growing animals due to potential for cartilage abnormalities
  • Use with caution in animals with ruptured tympanic membranes
  • Breeding, pregnant or nursing animals
  • Pets who have a history of seizures or other central nervous system disorders
  • Pets known to have had an allergic reaction to other quinolones and/or sulfonamides

Shake well before each use. Read and follow the label carefully.

Before using this product, a veterinary examination of the ear is needed to ensure the ear drum has not been perforated.

The ear should be clean and dry before using this product. Remove any debris, or crusty material with a non-irritating ear cleaning solution. It may be necessary to clip excessive hair from the ear.

Tilt the dog's head so that the affected ear is oriented upward. For dogs weighing up to 35 pounds, administer 5-10 drops. Dogs weighing more than 35 pounds, administer 10-15 drops per treatment. There should be enough product used to coat the ear lesions and the external ear canal. Following treatment, gently massage the ear to ensure complete distribution of the medication throughout the external ear canal. Apply twice daily for 14 days.

Apply the exact amount prescribed and only as often as directed. Missed doses reduce the effectiveness of therapy.

What if dose is missed?

If a dose is missed, apply it as soon as you can. If it is time already for the next dose, skip the missed dose and go back to the normal schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving medication?

Talk to your veterinarian about:

  • When will your pet need to be rechecked
  • What tests may need to be performed prior to and during treatment with this drug
  • Risks and benefits of using this drug

Tell your veterinarian about:

  • If your pet has experienced side-effects on other drugs/products
  • If your pet has experienced digestive upset now or ever
  • If your pet has experienced any other medical problems or allergies now or ever
  • All medicines and supplements that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
  • If your pet is pregnant or nursing or if you plan to breed your pet
Storage and Warnings:

Store between 4-25° C (40-77° F). Store in an upright position. Keep away from direct sunlight.

People should not take this drug. Keep this and all medication out of reach of children and pets. Avoid contact with eyes. Call your physician immediately if you accidentally take this product.

Pet owners who are allergic to quinolones (such as ciprofloxacin or norfloxacin) should avoid handling this drug.

Potential side effects:
  • Rare reports of ear irritation, acute inflammation of the ear canal and pinna (outer ear)
  • Lack of appetite, vomiting, diarrhea or hearing loss during treatment. Medical aid may be necessary.
  • If hearing or vestibular dysfunction (loss of balance, rhythmic eye motion, head tilt, circling) is noted during treatment, discontinue use of this product and contact your veterinarian
  • Damage to joint cartilage in immature dogs
  • If you notice anything unusual, contact your veterinarian
Can this drug be given with other drugs?
  • Yes, but if your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian

Contact your veterinarian immediately if pet receives more than the prescribed amount.

What else should I know?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, Enrofloxacin + Silver sulfadiazine Otic should only be given to the dog/cat for which it was prescribed. It should be given only for the condition for which it was prescribed.

This is just a summary of information about enrofloxacin. If you have any questions or concerns about Enrofloxacin + Silver sulfadiazine Otic or the condition it was prescribed for, contact your veterinarian.

Enrofloxacin/Silver Sulfadiazine
(Baytril Otic ®)

Common Drug Name
Enrofloxacin with silver sulfadiazine

Common Brand Names
Baytril Otic®
No generic products are available.

Store upright, at a temperature between 40-77°F, protected from light. 

Enrofloxacin and silver sulfadiazine are antibiotics used in combination for the treatment of susceptible bacterial infections of the ear in dogs. Silver sulfadiazine also has some activity against fungi, such as yeast.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty applying the medication, contact your veterinarian.
The ear should be thoroughly cleaned and dried before treatment. Remove any debris, or crusty material, etc. with a suitable non-irritating ear cleaning solution. Clip any excessive hair from the ear or treatment area, as directed.
Shake the bottle well before each use.
Apply the prescribed amount in the ear and gently massage the ear to distribute the medication.
If you miss a dose, apply it as soon as you remember. If it is almost time for the next dose, skip the application you missed and go back to the regular schedule.
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
May see hearing loss, vestibular (balance) disorders, or increased redness of the ear. If so, discontinue use and contact your veterinarian.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Do not use in animals hypersensitive (allergic) to it or other quinolone antibiotics and/or sulfonamides.
Avoid contact with the eyes.
The safe use of enrofloxacin/silver sulfadiazine in breeding animals or pregnant or lactating animals (female animals nursing their young) has not been evaluated.
May cause problems in the development of bones/joints of young growing animals, including large breeds of dogs under-24 months. Only use in growing animals, if under the supervision of a veterinarian.
Use with caution in animals with central nervous system (CNS) disorders, such as epilepsy, as it could possibly cause seizures.
It should not be used in animals with a perforated eardrum.
Consult with your veterinarian regarding the ear examinations and laboratory testing necessary prior to and during treatment with enrofloxacin/silver sulfadiazine.

Human Precautions
People with hypersensitivities (allergies) to other quinolone antibiotics, such as ciprofloxacin or norfloxacin should not handle the medication, since a photosensitivity reaction could occur just from contact.
In case of contact with human skin, wash skin with soap and water, and contact your physician if any redness or irritation occurs.

Drug, Food, and Test Interactions
Consult your veterinarian before using enrofloxacin/silver sulfadiazine with any other medications, including vitamins and supplements, since interactions may occur.

Signs of Toxicity/Overdose
May see lack of appetite, vomiting, diarrhea, hearing loss, vestibular (balance) disorders, or increased redness of the ear.
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times. Always consult your own veterinarian for specific advice concerning the treatment of your pet.


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