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Percorten V

Percorten V by Elanco

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The active ingredient in PERCORTEN-V is desoxycorticosterone pivalate (DOCP). It is a mineralocorticoid hormone and an analog of desoxycorticosterone. It is white, odorless, and stable in air. It is practically insoluble in water, sparingly soluble in acetone, slightly soluble in methanol, ether and vegetable oils. The molecular weight is 414.58. It is designated chemically as 21 (2,2-dimethyl-1-oxopropoxy)-pregn-4-ene-3,20-dione.

PERCORTEN-V is a white aqueous suspension. Each ml contains 25mg of desoxycorticosterone pivalate. Inactive ingredients are water for injection, methylcellulose, sodium carboxymethylcellulose, polysorbate 80, sodium chloride, and thimerosal.

Desoxycorticosterone pivalate (DOCP), like other adrenocorticoid hormones, is thought to act by controlling the rate of synthesis of proteins. It reacts with receptor proteins in the cytoplasm to form a steroid-receptor complex. This complex moves into the nucleus where it binds to chromatin that results in genetic transcription of cellular DNA to messenger RNA. The steroid hormones appear to induce transcription and synthesis of specific proteins which produce the physiologic effects seen after administration.

DOCP is a long-acting ester of desoxycorticosterone acetate (DOCA) which is recognized as having the same qualitative effects as the natural mineralocorticoid hormone aldosterone. The most important effect of DOCP is to increase the rate of renal tubular absorption of sodium. This effect is seen most intensely in the thick portion of the ascending limb of the loop of Henle. It also increases sodium absorption in the proximal convoluted tubule but this effect is less important in sodium retention. Chloride follows the sodium out of the renal tubule.

Another important effect of DOCP is enhanced renal excretion of potassium. This effect is driven by the resorption of sodium that pulls potassium from the extracellular fluid into the renal tubules, thus promoting potassium excretion. DOCP also acts to increase extracellular fluid volume. The enhanced retention of sodium, chloride and bicarbonate creates an osmotic
gradient that promotes water absorption from the renal tubules. The extracellular fluid volume is supported. This expands the blood volume and improves the venous return to the heart and cardiac output. The expanded blood volume and increased cardiac output may result in elevated blood pressure. PERCORTEN-V prevents the life threatening hypotensive shock and pre-renal azotemia observed in animals suffering from hypoadrenocorticism.

The effects of PERCORTEN-V on electrolytes and extracellular fluid volume are dependent on a functioning kidney. Animals suffering from hypovolemia, pre-renal azotemia, and inadequate tissue perfusion must be rehydrated with intravenous fluid (saline) therapy before starting PERCORTEN-V therapy. Primary renal disease should be ruled out before starting PERCORTEN-V therapy.

DOCP is an insoluble ester of desoxycorticosterone. The crystals are injected intramuscularly as a microcrystalline depot where they slowly dissolve over time.

For use as replacement therapy for the mineralocorticoid deficit in dogs with primary adrenocortical insufficiency.

Do not use this drug in pregnant dogs. Do not use in dogs suffering from congestive heart disease, severe renal disease or edema.Keep this and all drugs out of the reach of children. In case of human consumption, contact a physician or Poison Control Center immediately.

Desoxycorticosterone Pivalate 

Common Drug Name
Desoxycorticosterone pivalate (DOCP)

Common Brand Names
No generic products are available.

Store at room temperature in a tight, light resistant, childproof container. Protect from freezing. Do not mix with any other injectable medication.

DOCP is a mineralocorticoid used to treat Addison’s disease (adrenocortical insufficiency) in dogs and cats.

Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
Dosage varies per patient and is adjusted based upon blood electrolyte (e.g., sodium and potassium) levels. 
DOCP is an injectable medication. Shake the vial vigorously before each use, and follow your veterinarian’s directions on how to give the injection. Injections are usually given every 21-30 days. Treatment is needed for life.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give 2 doses at once.
This medication should only be given to the pet for whom it was prescribed.

Possible Side Effects
May see irritation at injection site.  If given at too low of a dose, may see signs of Addison’s disease (weakness, depression, lack of appetite, vomiting, and diarrhea). If given at too high of a dose may see increased thirst and urination, and edema (swelling, fluid accumulation in the limbs). If you observe any of these signs in your pet, contact your veterinarian immediately.
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

Not for use in animals hypersensitive (allergic) to it or drugs similar to it.
Do not use in pregnant or lactating animals (female animals nursing their young).
Do not use in patients with congestive heart failure, kidney disease, or edema (swelling).
Do NOT give DOCP intravenously (IV, into the vein).
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with DOCP.

Drug, Food, and Test Interactions
Consult your veterinarian before using vitamins and supplements, diuretics, insulin, digitalis, amphotericin B or potassium-depleting diuretics like Furosemide (Lasix, Salix), since interactions may occur. 

Signs of Toxicity/Overdose
May see an increase in drinking and urinating, changes in heart rate or rhythm due to abnormal blood levels of electrolytes, or edema. 
Heart enlargement is possible with long-term overdosing.
If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
Keep this and all other medications out of the reach of children and pets.

This information may not cover all possible uses, directions, side effects, precautions, allergic reactions, drug interactions, or withdrawal times.  Always consult your own veterinarian for specific advice concerning the treatment of your pet.


Customer Reviews

Average Customer Rating: (Excellent) based on 1 review
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423 of 786 found the following review helpful:
Percorten-V is the way to go for an Addison's dog!
5 Stars
by a member from Prescott, AZ on Aug 12, 2015

If your dog has Addison's, Percorten-V is a gold standard to manage Addison's disease. It keeps your dog consistant. I also use a "low dose" protocal to keep my dog feeling his best. Love this product!

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