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Advantage MULTI for Dogs

Advantage MULTI for Dogs by Bayer Animal Health Direct

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Advantage Multi® Topical Solution for Dogs


Advantage MULTI's Generic Name:

Imidacloprid + Moxidectin
 

Advantage MULTI General Description:

Imidacloprid + moxidectin is a topical insecticide and endectocide agent used in dogs and cats once a month to treat and control fleas, heartworms, hookworms and roundworms. It will also treat and control whipworms in dogs and ear mites in cats. Imidacloprid + moxidectin is applied between the shoulder blades every thirty days. Dogs should be older than 7 weeks of age and cats older than 8 weeks of age. It is important to note that the dog product should only be used on dogs while the cat product should only be used on cats. Imidacloprid + moxidectin is available in 4 sizes for dogs and 2 sizes for cats (based upon body weight).

What is Advantage MULTI for Dogs?
  • Imidacloprid + moxidectin contains a combination of insecticide and endectocide agents
  • Imidacloprid + moxidectin is applied topically once a month
Reasons for prescribing heartworm prevention Rx:
  • For the prevention of heartworm disease and the treatment and control of fleas infestations, hookworms and roundworms in dogs and cats
  • Used for the treatment and control of ear mites in cats
  • Used for the treatment and control of whipworms in dogs
  • Effective as a treatment for FAD (flea allergy dermatitis)
What dogs/cats should not take this Advantage MULTI for Dogs?
  • Dog product should only be used on dogs; Cat product should only be used on cats
  • Do not apply to irritated skin
  • Puppies less than 7 weeks of age or less than 3 pounds and cats less than 9 weeks of age or less than 2 pounds
  • Use with caution in Collies, Collie mixes, Australian shepherds and Australian shepherd mixes
  • Safety is unknown in breeding, pregnant or nursing animals
  • Use with caution in sick, debilitated or underweight pets
  • Heartworm positive patients
  • Pets known to have had an allergic reaction to imidacloprid and/or moxidectin or like products
Directions:

Be sure to follow the dosage instructions provided by your veterinarian. If you have difficulty applying the medication, contact your veterinarian.

Apply imidacloprid + moxidectin carefully to the skin between your pet's shoulder blades. For medium and larger dogs, squeeze contents evenly to three or four spots along the top of the back from the shoulder to the base of the tail. Use the entire contents of the tube that correctly corresponds with the body weight of your animal.

Do not allow pets to lick the product or ingest it in any way. If you have multiple pets, keep them separated for at least 30 minutes to prevent licking.

For heartworm prevention, repeat the application monthly all year long, or at a minimum, start one month before the first expected exposure to mosquitoes, continuing until one month after the last exposure to mosquitoes. Mark your calendar with the dates of subsequent treatments.

For flea treatment, administer monthly. Fleas already on the dog will be killed, but subsequent monthly treatments will prevent re-infestation of fleas hatching from the pet's environment.

For treatment and control of internal worms, a single dose will be adequate.

For ear mite treatment in cats, a single dose will be adequate. Monthly use will control any future infestations.

After applying this product to your pet, wash your hands with soap and water. Small children should avoid handling the treated pet for at least 2 hours after application.

For external use only. Do NOT give by mouth. Keep the product away from your pet's eyes and mouth.

Shampooing 90 minutes after treatment does not change its efficacy against heartworm disease. Shampooing or water immersion up to 4 days after treatment will not change the efficacy against flea infestations. However, shampooing as often as weekly may reduce the overall effectiveness against fleas. Additional applications of this product may be necessary. Discuss this with your veterinarian.

What if dose is missed?

If a dose is missed, apply it as soon as you can and resume the monthly dosing schedule. Do not give two doses at the same time.

What to tell/ask veterinarian before giving Advantage MULTI for Dogs?

Talk to your veterinarian about:

  • What tests may need to be performed prior to and during treatment with this drug
  • Risks and benefits of using this drug

Tell your veterinarian about:

  • If your pet has experienced side-effects on other drugs/products
  • If your pet has experienced any other medical problems or allergies now or ever
  • All medicines and supplements including flea and tick products that you are giving your pet or plan to give your pet, including those you can get without a prescription. Your veterinarian may want to check that all of your pet's medicines can be given together.
  • If your pet is pregnant or nursing or if you plan to breed your pet
Advantage MULTI for Dogs Storage and Warnings:
  • Store in a tight, light resistant, childproof container in a cool, dry place at room temperature away from heat and direct sunlight.
  • Causes eye irritation. Harmful if swallowed. Do not get in eyes or on clothing. Avoid contact with skin. Wash hands thoroughly with soap and water after handling.
  • People should not take this product. Keep this and all medication out of reach of children and pets. Call your physician immediately if you accidentally take this product.
  • Do not contaminate water or food by storage or disposal. Do not reuse empty container. Securely wrap original container in several layers of newspaper and discard in trash.
Potential side effects of Advantage MULTI for Dogs:
  • Hair may become damp, matted, oily, or stiff after application; skin may appear pink or have a slight powdery residue; medicinal odor. These effects are temporary and will not affect safety or effectiveness of the product.
  • Dogs: scratching, rubbing or licking at the application site; lethargy, decreased appetite, vomiting, excitement, facial swelling. Contact your veterinarian if you see any of these signs. If your dog ingests the product or licks the application site, serious adverse effects including depression, salivation, dilated pupils, incoordination, panting and tremors may occur.
  • Cats: lethargy and prolonged periods of sleep; agitation, excessive grooming, hiding, pacing; rubbing or scratching at the application site; increased salivation within an hour of treatment, increased drinking; coughing. If your cat licks the application site, you may see increased salivation, tremors, vomiting and loss of appetite.
  • Individual sensitivities may occur with any pesticide product. If they occur, consult your veterinarian immediately
Can this drug be given with other drugs?
  • There have been no drug interactions noted with this medication, but if your pet experiences any unusual reactions when taking multiple medications, contact your veterinarian
Overdosing?

Contact your veterinarian immediately if pet is exposed to more than the prescribed amount.

To report a suspected Adverse Reaction, call 1-800-422-9874.

What else should I know about Advantage MULTI for Dogs?

Notify your veterinarian if your animal's condition does not improve or worsens despite this treatment.

As with all prescribed medicines, imidacloprid + moxidectin should only be applied to the dog/cat for which it was prescribed. It should be given only to treat fleas.

This is just a summary of information about imidacloprid + moxidectin. If you have any questions or concerns about imidacloprid + moxidectin or for the condition(s) it was prescribed, contact your veterinarian.

Imidacloprid + Moxidectin
(Advantage Multi)
 
Common Drug Name
Imidacloprid plus moxidectin
 
Common Brand Names
Advantage Multi for Cats
Advantage Multi for Dogs
 
Note: Advantage Multi for Cats (in the 0.4 mL size only) has now been approved by FDA for some uses in ferrets.
 
Storage
Store at room temperature away from children and pets.
 
Uses
The combination of imidacloprid and moxidectin is used in dogs, cats and ferrets for the prevention of heartworm disease and the treatment and control of flea infestations. Treats and controls hookworms and roundworms in dogs and cats. Treats and controls ear mites in cats. In dogs, it treats circulating heartworm microfilariae, and treats and controls whipworms and sarcoptic mange.
 
Dose and Administration
Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian.
 
The combination of imidacloprid and moxidectin is applied topically (on the skin). It is NOT given orally. Follow the manufacturer’s recommendations for application. Do not apply to irritated skin.
If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once. This medication should only be given to the pet for whom it was prescribed.
 
Possible Side Effects
Potential side effects in dogs include scratching, rubbing, or licking the application site; lethargy, decreased appetite, or hyperactivity. A medicinal odor and residue at the application site may also be seen. If a dog ingests the product or licks the application site, serious adverse effects may occur including depression, salivation, incoordination, panting and tremors. 
 
Potential side effects in cats include lethargy and prolonged periods of sleep; behavioral changes including agitation, excessive grooming, hiding, pacing; etc.; discomfort at the application site (rubbing, scratching, etc.); increased salivation with-in 1 hour of treatment; increased drinking; or coughing. If a cat licks the application site may see increased salivation, tremors, vomiting, and decreased appetite.
 
Potential side effects in ferrets include itchiness, scratching, scabbing, redness, wounds and inflammation at the application site, and lethargy.
 
Consult your veterinarian if you notice any of the above side effects in your pet.
Hair may appear stiff, matted, oily, or damp after application.
 
To report a possible adverse reaction to this product, contact the manufacturer (Bayer Health Care) at 1-800-422-9874. For questions, call the manufacturer at 1-800-255-6826.
 
If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.
 
Precautions in Animals:
Not for use in animals hypersensitive (allergic) to imidacloprid or moxidectin.
Do not use in animals who are sick, debilitated, or underweight. 
 
Do not use in cats under 9 weeks of age or less than 2 pounds, dogs under 7 weeks of age or less than 3 pounds, or in ferrets less than 2 lbs. 
 
The safety of imidacloprid plus moxidectin in breeding, pregnant or lactating animals (female animals nursing their young) has not been determined. The safety of imidacloprid plus moxidectin in geriatric animals with potential health problems has not been determined.
 
Do not use the dog product on cats or ferrets. Do not allow any animal to lick the application site, for 30 minutes. Separation of treated animals may be necessary.
 
Consult with your veterinarian regarding the physical examinations and laboratory testing necessary prior to and during treatment with imidacloprid plus moxidectin.
 
Human Precautions: 
Children should not come in contact with the application site, for 30 minutes after application. Can cause eye irritation and be harmful if swallowed. Wash hands thoroughly with soap and water after handling. 
 
Drug, Food and Test Interactions
Notify your veterinarian of any other medications, including vitamins, supplements, and other flea/tick products your pet is receiving while using imidacloprid plus moxidectin on your pet.
 
Signs of Toxicity/Overdose
May include depression, increased salivation, tremors, or incoordination. If you observe any of these signs in your pet, or suspect your pet has had an overdose,  contact your veterinarian immediately. 
 
Keep this and all other medications out of the reach of children and pets.
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